Voltammetric Determination of Antidepressant Imipramine in Pharmaceutical Preparations Using Boron-Doped Diamond Electrode

Authors

  • K. Cinková Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia
  • M. Maťokárová Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia
  • I. Sálusová Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia
  • A. Planková Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovakia
  • B. Brtková Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia
  • K. Borovská Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia
  • M. Marton Institute of Electronics and Photonics, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia
  • M. Vojs Institute of Electronics and Photonics, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia
  • Ľ. Švorc Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia

Keywords:

imipramine, boron-doped diamond electrode, differential pulse voltammetry, detection limit

Abstract

Herein, the direct electroanalytical determination of antidepressant imipramine using a boron-doped diamond electrode is presented. Cyclic and linear sweep voltammetric measurements revealed one distinct, irreversible and diffusion-controlled oxidation peak at +0.75 V (vs. Ag/AgCl) and oval-shaped peaks at +1.0 V and +1.5 V in the presence of Britton-Robinson buffer at pH 9. Using differential pulse voltammetry, the peak current of IMIP was found to be linear function of the concentration from 1.5 to 19.4 µM with the obtained detection limit of 0.5 µM and good repeatability (relative standard deviation of 5.4 % for n = 20 at 1.5 µM IMIP). The practical usefulness of the developed method was successfully manifested on the analysis of pharmaceutical tablets with significant recoveries (99.0–100.4 %). Finally, boron-doped diamond electrode could be considered as an alternative to widely used chemically modified electrodes in antidepressant sensing and may be applied as a sensitive electrochemical sensor in routine pharmaceutical analysis.

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Published

2017-06-15

How to Cite

Cinková, K., Maťokárová, M., Sálusová, I., Planková, A., Brtková, B., Borovská, K., Marton, M., Vojs, M., & Švorc, Ľ. (2017). Voltammetric Determination of Antidepressant Imipramine in Pharmaceutical Preparations Using Boron-Doped Diamond Electrode. Chemické Listy, 111(6), 392–397. Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/74

Issue

Vol. 111 No. 6 (2017)

Section

Articles

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